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Scientific innovation

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Biofilm Penetration vs. CPC

Biofilm Penetration vs. CPC

Recommend a rinse with superior plaque biofilm penetration.

LISTERINE® Antiseptic penetrates plaque biofilm deeper than cetylpyridinium chloride (CPC)*

Rinses containing cetylpyridinium chloride only go so far, and in lab studies they have been proven to kill less bacteria.42

Essential Oils kill bacteria associated with plaque and gingivitis by disrupting the bacterial cell wall resulting in cell death

  • Penetrate and destroy bacterial cell membranes45
  • Extract endotoxins from plaque bacteria that cause inflammation45
  • Do not promote resistance despite daily use45

Recommend a rinse with deeper plaque biofilm penetration:  1.8x more plaque biofilm penetration (confocal microscopy of living biofilm cells [green] and dead biofilm cells [red] at deepest layer).42

Killing 2x More Bacteria than CPC
Killing 2x More Bacteria than CPC
Killing 2x More Bacteria than CPC

Killing 1.8x More Bacteria than CPC1

48 hour saliva grown plaque biofilm, treated 1x immediately before imaging (green is live, red is dead bacteria – 63x magnification)

See in 3D animation how deeply LISTERINE® Antiseptic penetrates plaque biofilm:

*Lab study: Mixed species biofilm growth 48 hours prior to 30-second treatment with mouthrinse or sterile water.

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Reduction in gingivitis

LISTERINE® Antiseptic results in 46% more healthy gingival sites than CPC (Crest® Pro-Health™)44

65% reduction in gingevitis vs competitor

LISTERINE® Antiseptic reduces gingivitis by 65% more than Crest® Pro-Health™ 42