Chemotherapeutic inhibition of supragingival dental plaque and gingivitis development4
- DePaola LG, Overholser CD, Meiller TF, Minah GE, Niehaus C. J Clin Periodontol. 1989;16:311-315.
Determine the efficacy of a mouthrinse used as a supplement to regular oral hygiene measures on supragingival dental plaque and gingivitis (N=107).
Double-blind, controlled clinical study of healthy male and female subjects (aged 18-60 years) with preexisting plaque and gingivitis but without evidence of periodontitis.
Subjects were randomized to either:
LISTERINE® Antiseptic OR 5% hydroalcohol solution
Following a complete prophylaxis on Day 1, subjects were instructed to:
Rinse with 20 mL of their assigned rinse for 30 seconds, 2x daily 6 months*
Plaque levels, gingivitis, and extrinsic tooth stain were assessed at:
- Month 3
- Month 6
LISTERINE® Antiseptic inhibited the accumulation of supragingival dental plaque by 34.4% (P<0.001) and the development of gingivitis by 33.7% (P<0.001) at 6 months compared to hydroalcohol control.
When used as a supplement to normal oral hygiene following a prophylaxis, LISTERINE® Antiseptic significantly reduced plaque and gingivitis over a six-month period, without an increase in extrinsic tooth stain.
* Subjects followed their usual oral hygiene and dietary habits.