Scientific innovation


Clinical Studies - Lamster

Clinical Studies - Lamster

The effect of LISTERINE® Antiseptic on reduction of existing plaque and gingivitis43

- Lamster IB, Alfano MC, Seiger MC, Gordon JM. Clin Prev Dent. 1983;5:12-16.


Evaluate the effect of LISTERINE® Antiseptic on existing dental plaque and gingivitis over the course of a 6-month trial (N=129).


Randomized, double-blind study of subjects (aged ≥18 years) with preexisting plaque and gingivitis.

Lamster study

Subjects were randomized to either:

  • LISTERINE® Antiseptic
  • OR
  • Hydroalcohol (26.9%) Solution
  • OR
  • Water


When compared with water, LISTERINE® Antiseptic reduced dental plaque by 22.2% and gingivitis by 28.2% at 6 months. When compared with vehicle, LISTERINE® Antiseptic reduced dental plaque by 20.8% and gingivitis by 27.7% at 6 months, respectively.

Data from Lamster study


LISTERINE® Antiseptic, when used twice daily for 30 seconds, is effective in controlling plaque accumulation and gingivitis in a population that did not receive a prophylaxis.

*Subjects were instructed to follow their usual oral hygiene regimen and use of dental floss was permitted to remove trapped food. †26.9% hydroalcoholic vehicle containing all ingredients in LISTERINE® Antiseptic except its essential oils.